Article Sidebar

Download
PDF (Bahasa Indonesia)
Statistic
Read Counter : 0 Download : 0

Downloads

Download data is not yet available.

Main Article Content

Abstract

Drug interactions may cause adverse drug reactions (ADRs), particularly in patients with hypertension and comorbidities who receive multiple medications concomitantly. This study aimed to identify suspected ADRs associated with drug interactions in patients receiving amlodipine and to assess causality using the Naranjo Algorithm. This was a descriptive study with a cross-sectional design and a prospective approach conducted among patients with hypertension at a hospital in Palu, Indonesia, from October to December 2023. Data were collected through patient interviews and medical record reviews, analyzed descriptively, and assessed using the Naranjo Algorithm. Among the 50 patients studied, four (8%) experienced suspected ADRs associated with the concomitant use of amlodipine and other medications. Three of the 39 patients receiving simvastatin (7.69%) reported muscle pain and weakness, whereas one of the eight patients receiving metformin (12.50%) experienced hypoglycemia, with a random blood glucose level of 37 mg/dL. The Naranjo Algorithm yielded a score of +5 for the cases involving simvastatin and +6 for the case involving metformin, both of which were classified as probable. These findings highlight the importance of clinical monitoring and medication review in patients receiving amlodipine concomitantly with other medications. However, the causal relationship between the drug interactions and the observed clinical manifestations should be interpreted cautiously.

Keywords

Drug Interactions Adverse Drug Reactions Amlodipine Naranjo algorithm

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Amelia Rumi, Universitas Tadulako

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Andi Atirah Masyita, Universitas Tadulako

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Muhammad Rinaldhi Tandah, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Inggrid Alvionita H. Lagoa, Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Abdurrahman Hasymi, Departemen Histologi, Fakultas Kedokteran, Universitas Alkhairaat

Departemen Histologi, Fakultas Kedokteran, Universitas Alkhairaat

Ratih Pratiwi Sari, Program Studi Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin

Program Studi Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Banjarmasin
How to Cite
Rumi, A., Masyita, A. A., Tandah, M. R., Lagoa, I. A. H., Hasymi, A., & Sari, R. P. (2026). Analisis Reaksi Obat Tidak Diinginkan Yang Terkait Dengan Interaksi Obat Pada Pasien Yang Dirawat Dengan Amlodipin. Borneo Journal of Pharmascientech, 10(2), 376-389. https://doi.org/10.59053/bjp.v10i2.830
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Agustin, O.A. dan Fitrianingsih. 2020. 'Penilaian Interaksi Obat Berdasarkan Kategori Signifikansi Klinis dari Pola Resep Rawat Jalan di Apotek X Jambi', Jurnal Elektronik E-SEHAD, 1(1), hlm. 1-10. Tersedia di: https://online-journal.unja.ac.id/e-sehad/article/view/10759.
  2. Andayani, T. M., Rahmawati, F., Rokhman, M. R., Sampurno, Mayasari, G., Nurcahya, B. M., Arini, Y. D., Arfania, M., Mpila, D. A., Octasari, P. M., Ningrum, A. D., Irnayanti, dan Intiyani. 2020. Masalah terkait obat: Identifikasi, faktor risiko, dan pencegahan. Yogyakarta: UGM PRESS.
  3. Ardhany, S.D., Pandaran, W. dan Pratama, M.R.F. 2018. 'Profil Obat Antihipertensi di Rumah Sakit Mas Amsyar Kasongan Kabupaten Katingan', Jurnal Farmasi Borneo, 1(1), hlm. 47-50. Tersedia di: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3231771.
  4. Costa, J. P. da, Alves, G. A. de C., Guedes, É. da C., Fonseca, F. P. de B., Souto, R. Á. D. de M., Lopes, P. Q., and Golzio, A. M. F. de O. 2022. ‘Analysis of potential drug interactions in medical clinic sector in a Hospital of João Pessoa - PB’, Brazilian Journal of Pharmaceutical Sciences, 58. doi:10.1590/s2175-97902022e18943.
  5. Darmayanti EY, Puspitasari CE, dan Hasina R. Tanpa Judul Profil Masalah Terkait Obat (MTO) Penggunaan Antibiotik pada Pasien Anak dengan Diare Infektif di RSUD Provinsi NTB pada Tahun 2018: Profil Masalah Terkait Obat (MTO) Penggunaan Antibiotik pada Pasien Anak dengan Diare Infektif di Provinsi NTB. Jurnal Ilmu dan Kesehatan 2021; 3(3), hlm. 500-504. doi: 10.25026/jsk.v3i3.428.
  6. Dewi, R., Hadriyati, A., & Situngkir, E. N. 2025. 'Analisis Interaksi Obat Antidiabetik terhadap Clinical Outcome Pasien DM Tipe 2 di RS X Jambi'. Jurnal Akademika Baiturrahim Jambi, 14(1), hlm. 80-92.
  7. Farmer, M.J.S., Contractor, A. and Allgaier, J. 2022. ‘Amlodipine Overdose: Is High Dose Insulin Ready for Prime Time’, Hearts, 4(1), pp. 1–11. doi:10.3390/hearts4010001.
  8. Hayati, B., Ariyani, H. dan Ruslinawati. 2020. 'Interaksi Obat Potensial dalam Meresepkan Pasien Diabetes Melitus Tipe 2 di Apotek X', Jurnal Ilmu Farmasi Terkini, 3(2), hlm. 249-255.
  9. Hayes, D. K., Jackson, S. L., Li, Y., Wozniak, G., Tsipas, S., Hong, Y., Thompson-Paul, A. M., Wall, H. K., Gillespie, C., Egan, B. M., Ritchey, M. D., and Loustalot, F. 2022. ‘Blood Pressure Control Among Non-Hispanic Black Adults Is Lower Than Non-Hispanic White Adults Despite Similar Treatment With Antihypertensive Medication: NHANES 2013-2018’, American Journal of Hypertension, 35(6), pp. 514–525. doi:10.1093/ajh/hpac011.
  10. Khusna N, Murdiana, H. 2021. 'Identifikasi Masalah Terkait Obat (MTO) Obat Antihipertensi pada Pasien Hipertensi di Puskesmas Dharma Rini Temanggung', Jurnal Farmasi dan Kesehatan Indonesia, I(2), hlm. 13-26.
  11. Korucu, F. C., Senyigit, E., Köstek, O., Demircan, N. C., Erdogan, B., Uzunoglu, S., and Cicin, I. 2018. ‘A retrospective study on potential drug interactions: A single center experience’, Journal of Oncological Sciences, 4(2), pp. 80–84. doi:10.1016/j.jons.2018.06.001.
  12. Kusumawardani, L., Andrajati, R. and Nusaibah, A. 2020. ‘Drug-related problems in hypertensive patients: A cross-sectional study from Indonesia’, Journal of Research in Pharmacy Practice, 9(3), p. 140. doi:10.4103/jrpp.jrpp_20_16.
  13. Madania, Rasdianah, N., Dalu, C. M., dan Pakaya, M. 2022. 'Interaksi Obat Potensial pada Pasien Hipertensi dan Diabetes Melitus Tipe 2 di Instalasi Rawat Jalan RSUD Toto Kabila', Al-Idarah: Jurnal Manajemen dan Bisnis Islam, 3(1), hlm. 59-60. Tersedia di: Pharmacoscript Volume 5 No. 1 Februari 2022%0AMadania et al./ Pharmacoscript, Volume 5, No, 1, Februari 2022, 56-61.
  14. Mariam, S., Salsabilila Y, A. dan Kurniasih, N. 2022. 'Evaluasi Kejadian Interaksi Obat Antihipertensi pada Pasien Rawat Jalan di Puskesmas Tanah Sareal', Jurnal Pharmamedica, 7(2), hlm. 157-164. doi:10.47219/ath.v7i2.189.
  15. Made, L., Roslandari, W., Illahi, R. K., dan Lawuningtyas, A. 2020. 'Hubungan Antara Dukungan Keluarga dan Tingkat Kepatuhan Pengobatan Pasien Hipertensi Rawat Jalan dalam Program Manajemen Penyakit Kronis', Jurnal Farmasi Indonesia, 5(2), hlm. 131-139.
  16. Morales-Ríos, O., Jasso-Gutiérrez, L., Reyes-López, A., Garduño-Espinosa, J., and Muñoz-Hernández, O. 2018. ‘Potential drug-drug interactions and their risk factors in pediatric patients admitted to the emergency department of a tertiary care hospital in Mexico.’, PLOS ONE, 13(1), p. e0190882. doi:10.1371/journal.pone.0190882.
  17. Mahamudu, Y.S., Citraningtyas, G. dan Rotinsulu, H. 2017. 'Pasien Hipertensi Primer di Instalasi Rawat Jalan Rsud Luwuk Periode Januari - Maret 2016', Jurnal Ilmiah Farmasi, 6(3), hlm. 1-9.
  18. Parellangi, A. 2018. Keperawatan Home Care: Aplikasi Praktik Berbasis Bukti. Yogyakarta: Penerbit Andi.
  19. Parisa, N., Marylin, D.T., dan Theodorus. 2022. ‘Evaluasi Rasionalitas dalam Meresepkan Metformin (Kelompok Biguanid) di Rumah Sakit Umum Dr. Mohammad Hoesin Palembang’, Bioscientia Medicina: Journal of Biomedicine and Translational Research, 6(3), hlm. 1530–1535. doi:10.37275/bsm.v6i3.471.
  20. Purnamasari, Komariyah, I. 2020. ' Sikap Lansia terhadap Kejadian Hipertensi di Puskesmas Kutai, Kabupaten Tangerang', Prosiding Simposium Nasional Multidisipliner Sinamu, 2, hlm. 1-10.
  21. Rikomah, S.E. 2018. Farmasi Klinik. Yogyakarta: Deep Publish.
  22. Rohmawati, D.L. 2020. 'Pemberdayaan Masyarakat yang Peduli dengan Hipertensi sebagai Upaya untuk Menurunkan Tekanan Darah melalui Terapi Komplementer', Jurnal Pengembangan Kesehatan Masyarakat, 1(1), hlm. 62-67.
  23. Rumi, A. and Fitriana, A. 2021. ‘The Evaluation of Fasting Plasma Glucose (FPG) Levels in Hypertensive Patients Using Calcium Channel Blocker (CCB) Drugs Class in Undata Regional Hospital’, Galenika Journal of Pharmacy (e-Journal), 7(2), pp. 166–180. doi:10.22487/j24428744.2021.v7.i2.15463.
  24. Rumi, A. dan Safarudin. 2016. Belajar Mudah Farmasi Klinis. Yogyakarta: Kanisius Publish.
  25. Sapwal, J.M., Taufandas, M. and Hermawati, N. 2021. 'The Relationship between Family Support and Hypertension Diet Adherence in the Elderly in Ladon Hamlet, Wanasaba Health Center Working Area', Medika Hutama Journal, 2(2), pp. 801-815. Available at: http://www.jurnalmedikahutama.com/index.php/JMH/article/view/173.
  26. Saraswati, M. D., Ardiana, S. M., Suprapti, B., Assegaf, M. Y., Suharjono, S., and Hamidah, K. F. 2022. 'Potential Drug-Drug Interactions in Ambulatory Patients with Hypertension: a Retrospective Study', Indonesian Journal of Pharmacy and Pharmaceutical Sciences, 9(1), pp. 69-74. doi:10.20473/jfiki.v9i12022.69-74.
  27. Shukla, A., Jhaj, R., Misra, S., Ahmed, S., Nanda, M., and Chaudhary, D. 2021. ‘Agreement between WHO-UMC causality scale and the Naranjo algorithm for causality assessment of adverse drug reactions. Journal of Family Medicine and Primary Care, Journal of Family Medicine and Primary Care, 10(9), p. 3303. doi:10.4103/jfmpc.jfmpc_831_21.
  28. Sutherland, A., Phipps, D. L., Tomlin, S., and Ashcroft, D. M. 2019. ‘Mapping the prevalence and nature of drug-related problems among hospitalized children in the United Kingdom: A systematic review’, BMC Pediatrics, 19(1), pp. 1–14. doi:10.1186/s12887-019-1875-y.
  29. Tuloli, T. S., Djuwarno, E. N., Hiola, F., Ramadhani, F. N., dan Mudjidu, D. H. 2022. 'Studi tentang Rasionalitas Penggunaan Obat Antihipertensi pada Kasus Rawat Jalan.', Jurnal Syifa Sciences and Clinical Research, 4(3). doi:10.37311/jsscr.v4i3.16018.
  30. Tumundo, D.G., Wiyono, W.I. dan Jayanti, M. 2021. 'Tingkat Kepatuhan Penggunaan Obat Antihipertensi pada Pasien Hipertensi di Puskesmas Kema, Kabupaten Minahasa Utara', Pharmacon, 10(4), hlm. 1121-1128. Tersedia di: https://ejournal.unsrat.ac.id/index.php/pharmacon/article/view/37409.
  31. Vilar, S., Friedman, C. and Hripcsak, G. 2018. ‘Detection of drug-drug interactions through data mining studies using clinical sources, scientific literature, and social media’, Briefings in Bioinformatics, 19(5), pp. 863–877. doi:10.1093/bib/bbx010.