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Abstract

Acne is a common inflammatory skin disorder affecting both adolescents and adults, primarily caused by the colonization of Propionibacterium acnes, which induces skin inflammation. The development of natural-based anti-acne agents may offer a safer alternative to synthetic drugs. Zingiber cassumunar Roxb. (bangle rhizome) contains flavonoids, terpenoids, saponins, and essential oils known for their strong antibacterial properties. Aim: this study aimed to evaluate the antibacterial activity of Z. cassumunar rhizome extracts against P. acnes and to formulate a topical anti-acne gel. Method: extraction was conducted using successive maceration with n-hexane, ethyl acetate, and 70% ethanol. Antibacterial activity was determined by the disk diffusion method, and gels containing n-hexane extract at concentrations of 5%, 10%, and 15% were evaluated for their physical quality. Results: the n-hexane extract exhibited the highest antibacterial activity, producing an inhibition zone of 7.56 ± 0.11 mm. The 15% extract gel (F3) showed the strongest antibacterial effect (9.26 ± 0.08 mm) and met all physical quality requirements. Conclusion: these findings indicate that the n-hexane extract gel of Z. cassumunar rhizome possesses promising potential as a natural topical formulation for treating acne caused by P. acnes.

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Author Biographies

Hana Nurhasanah, Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Tresna Lestaria, Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Ira Rahmiyani, Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Dewi Peti Virgianti, Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya
How to Cite
Nurhasanah, H., Lestaria, T., Rahmiyani, I., & Virgianti, D. P. (2026). Aktivitas Antibakteri dan Formulasi Gel Topikal Ekstrak Akar Zingiber cassumunar Roxb. Terhadap Propionibacterium acnes. Borneo Journal of Pharmascientech, 10(1), 433-443. https://doi.org/10.59053/bjp.v10i1.805
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