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Abstract

South Kalimantan has a unique topography that includes tidal areas and swamps, and peatlands. One of the natural resources that grows well in this area is the galam tree (Melaleuca cajuputi). Traditionally, this plant has been used to treat various inflammatory conditions, such as intestinal inflammation, sore throat, itchy skin, and rheumatism. M. cajuputi contains flavonoid compounds that are believed to have anti-inflammatory properties. This study aimed to determine the anti-inflammatory activity of ethanol extracts and n-hexane fractions of M. cajuputi leaves from South Kalimantan using a protein denaturation inhibition method with IC50 values as the parameter. Sodium diclofenac was used as the positive control in this study. The results of the anti-inflammatory activity test showed that the IC50 values for sodium diclofenac, ethanol extract, and n-hexane fraction of M. cajuputi leaves were 14.948; 51.577; and 61.700 ppm, respectively. Statistical analysis revealed a significant difference between the IC50 value of sodium diclofenac and those of the ethanol extract and n-hexane fraction. Based on the study conducted, it can be concluded that the ethanol extract and n-hexane fraction have anti-inflammatory activity, although their potency is lower than that of sodium diclofenac

Keywords

M. cajuputi Galam Antiinflamation Protein Denaturation Extract and fraction

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Author Biographies

Sutomo Sutomo, Bagian Biologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Bagian Biologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Arnida Arnida, Bagian Biologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Bagian Biologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Amalina Amalina, Program Studi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Program Studi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Fadlilaturrahmah Fadlilaturrahmah, Bagian Kimia Farmasi Universitas Lambung Mangkurat

Bagian Kimia Farmasi Universitas Lambung Mangkurat

Mia Fitriana, Bagian Teknologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat

Bagian Teknologi Farmasi Fakultas MIPA Universitas Lambung Mangkurat
How to Cite
Sutomo, S., Arnida, A., Amalina, A., Fadlilaturrahmah, F., & Fitriana, M. (2025). Potensi Antiinflamasi Ekstrak dan Fraksi n-Heksana Daun Galam (Melaleuca cajuputi) Asal Kalimantan Selatan. Borneo Journal of Pharmascientech, 9(2). https://doi.org/10.59053/bjp.v9i2.754
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References

  1. Astika, R. Y., F. Sani K & Elisma. 2022. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) pada Mencit Putih Jantan. Jurnal Ilmiah Manuntung. 8: 14–23.
  2. Audina, M., Yuliet & K. Khaerati. 2018. Efektivitas Antiinflamasi Ekstrak Etanol Daun Sumambu (Hyptis capitata Jacq.) pada Tikus Putih Jantan (Rattus norvegicus L.) yang Diinduksi Dengan Karagenan. Biocelebes. 12: 17–23.
  3. Bakkali F., S. Averbeck, D. Averbeck, & M. Idaomar. 2008. Biological effects of essential oils-a review. Food Chem Toxicol, 46 (2) : 446-75
  4. Chen, L., H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Y. Li, X. Wang & L. Zhao. 2017. Inflammatory Responses and Inflammation-Associated Diseases in Organs. Oncotarget. 9: 1–15.
  5. Fadlilaturrahmah, F., J. Amilia, Y. Sukmawaty & N. Wathan. 2022. Identifikasi Fitokimia dan Uji Aktivitas Antiinflamasi In Vitro Fraksi N-Heksana Kapur Naga (Calophyllum soulattri Burm F) dengan Metode Uji Penghambatan Denaturasi Protein Menggunakan Spektrofotometer Uv-Vis. Jurnal Pharmascience. 9: 355-367.
  6. Forestryana, D. & Arnida. 2020. Skrining Fitokimia dan Analisis Kromatografi Lapis Tipis Ekstrak Etanol Daun Jeruju (Hydrolea spinosa L.). Jurnal Ilmiah Farmako Bahari. 11: 113-124.
  7. Ge, J., Z. Liu, Z. Zhong, L. Wang, X. Zhuo, J. Li, X. Jiang, X. Ye, T. Xie, R. Bai. 2022. Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery. Bioorganic Chemistri (124), 105817
  8. Hakim, L. & N. E. N. Sugijanto. 2014. Aktifitas Antimikroba Fraksi-Fraksi dari Ekstrak Etil Asetat yang Diisolasi dari Aglaia Odorata Lour. Berkala Ilmiah Kimia Farmasi. 3: 29–34.
  9. Harborne, J. B. 1987. Metode Fitokimia. ITB, Bandung.
  10. Ihsan, H., I. S. Pratama & N. I. Hanifa. 2021. Uji Aktivitas Antiinflamasi Infusa Bunga Pukul Empat (Mirabilis jalapa L.) secara In Vitro. Acta Pharmaciae Indonesia : Acta Pharm Indo. 9: 21–30.
  11. Isnaini, A. Biworo, H. Khatimah, K. M. Gufron & S. R. Puteri. 2021. Aktivitas Antibakteri dan Antijamur Ekstrak Galam (Melaleuca cajuputi Subsp. Cumingiana (Turcz.) Barlow) Ttrhadap Bakteri E.coli Dan Jamur C. albicans. Journal Od Agromedicine and Medical Sciences. 7: 79–83.
  12. Latief, M., A. T. Fisesa, P. M. Sari & I. L. Tarigan. 2021. Aktivitas Antiinflamasi Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) pada Mencit Terinduksi Karagenan. Jurnal Farmasi Sains Dan Praktis. 7: 144–153
  13. Maifitrianti, L. R. Sjahid, Nuroh, R. A. M. Acepa & W. D. Murti. 2019. Aktivitas Antiinflamasi Fraksi-Fraksi Ekstrak Etanol 95% dari Daun Kersen (Muntingia calabura L.) pada Tikus Putih Jantan. Pharmaceutical Journal of Indonesia. 16: 1–16.
  14. Mulyani, T., S. Setyahadi & A. E. Wibowo. 2023. Uji Aktivitas Antiinflamasi Kombinasi Ekstrak Daun Torbangun (Plectranthus amboinicus (Lour.) Spreng.) dan Ekstrak Daun Kelor (Moringa oleifera Lam.) dengan Metode Penghambatan Denaturasi Protein. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia). 20: 26–32.
  15. Munadi, R., Jasmiadi & E. Rossalinda Ruslan. 2024. Uji Aktivitas Antioksidan Hasil Fraksinasi Ekstrak Metanol Daun Ilalang (Imperata cylindrica Linn.) dengan Metode DPPH. Cokroaminoto Journal of Chemical Science. 6: 1–4.
  16. Muthia, F., S. Sukmawati & F. Fitriana. 2023. Antibacterial Activity of Ethanol Extract of Qust Al Hindi Plant Root (Saussurea lappa) Against Bacteria Staphylococcus aureus And Escherichia coli By TLC-Bioautography. Journal Microbiology Science. 3: 20–29.
  17. Rahmadani, D. & H. M. Nasution. 2021. Potensi Antioksidan Fraksi Etil Asetat dan Fraksi N-Heksana Ekstrak Etanol Kulit Buah Asam Jawa (Tamarindus indica L.) terhadap Penangkalan Radikal Bebas. FARMASAINKES: Jurnal Farmasi, Sains, Dan Kesehatan. 1: 28–37.
  18. Ratri, L. K., C. D. A. Nugraha, N. H. Rahma & D. N. Afifah. 2022. Potensi Tangkai Terong (Solanum melongena) sebagai Immune Booster. Journal of Nutrition College. 11: 105–113.
  19. Rosmainar L, W. Nugroho, I.N. Sudyana, N. Ayuchecaria. 2023. Senyawa Minyak Atsiri Dari Tumbuhan Galam (Melaluca sp). Jurnal Cendekia Kimia 01 (02) : 93-98.
  20. Saraswati I., Muslimin, Farmaditya E.P., Hardia, Renni Y., Rahma Y.N., Alviona D.A., Tangkas M.P., Vinka D.A, Novi K. 2024. Pengaruh Waktu Pemanasan Dan Pengasaman Terhadap Kadar Albumin Ekstrak Ikan Gabus. JPHPI, 27 (2) : 104-111.
  21. Silverstein, R. M., Webster, F. X., & Kiemle, D. J. (2014). Spectrometric Identification of Organic Compounds. Wiley.
  22. Tiwari, P., Kaur, M. and Kaur, H. (2011) "Phytochemical screening and extraction: A review." International Pharmaceutica Sciencia, 1(1) : 98–106.
  23. Wardhani, A. H. Ramadani, F. Widyaningrum & V. Famelia. 2023. The Effect of Extraction Method on Total Flavonoid Content of Ageratum conyzoides Ethanol Extract. Journal Of Biology Education. 6: 136–148.