Article Sidebar

Download
Statistic
Read Counter : 20

Downloads

Download data is not yet available.

Main Article Content

Abstract

Hypertension is a major risk factor for cardiovascular diseases and can lead to serious complications if not managed optimally. This study aims to evaluate the effects and optimal dose of ethanol extract of purslane herb (Portulaca oleracea L.) in reducing systolic and diastolic blood pressure in hypertensive male rats. The rats were divided into several groups: a negative control, a positive control (captopril), and three treatment groups receiving ethanol extract of purslane at doses of 100, 200, and 300 mg/kg body weight. Systolic and diastolic blood pressure were measured throughout the study to assess the antihypertensive activity of the extract. The results showed that purslane extract at doses of 100, 200, and 300 mg/kg body weight significantly lowered blood pressure, likely due to bioactive compounds such as flavonoids, saponins, and phenols. These compounds exhibit vasodilatory activity, ACE enzyme inhibition, and diuretic effects that contribute to blood pressure reduction in the hypertensive rat model. Ethanol extract of purslane herb (Portulaca oleracea L.) was found to have a significant effect in reducing systolic and diastolic blood pressure in hypertensive rats, with the optimal dose for significant blood pressure reduction being 300 mg/kg body weight

Keywords

Hypertension Purslane Portulaca oleracea L Rattus norvegicus

Article Details

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite
Putra, B., Azizah, R. N., Kosman, R., & Iskandar , A. N. (2025). Pengaruh Pemberian Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Terhadap Penurunan Tekanan Sistolik Diastolik Pada Tikus Putih (Rattus norvegicus) Model Hipertensi. Borneo Journal of Pharmascientech, 9(2). https://doi.org/10.59053/bjp.v9i2.642
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Afifah, N. N., Mulyani, Y., & Yuniarto, A. (2021). Review: Pengaruh Tanaman Obat Yang Beraktivitas Hipertensi Terhadap Ekspresi Gen Reseptor ACE-1 dan ACE 2. Jurnal Mandala Pharmacon Indonesia, 7(1), 9–31. https://doi.org/10.35311/JMPI.V7I1.64
  2. Afrianti, R., Novelni, R., & Yulinda, I. (2020). Pengaruh Pemberian Ekstrak Etanol Daun Sembung (Blumea balsamifera (L.) DC) Sebagai Antihipertensi Terhadap Tikus Putih Jantan. JAFP (Jurnal Akademi Farmasi Prayoga), 5(1), 1–10. https://doi.org/10.56350/JAFP.V5I1.31
  3. Arifin, S., Emelda, A., Santi, I., Putrisari, A., Rahmaputri, T., Intan, N., Al Adawiyah, R. (2024). Effects of Pamelo Orange Peel (Citrus maxima) Ethanol Extract on Macroscopic Kidney and Heart of Hypertensive Rats: Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 10(1), 107–116. https://doi.org/10.22487/J24428744.2024.V10.I1.16946
  4. Ariwibowo, A. I., Hilmi, I. L., & Salman, S. (2023). Research Article: Efektivitas Pengobatan Herbal pada Pasien Hipertensi. Jurnal Surya Medika (JSM), 9(2), 34–40. https://doi.org/10.33084/JSM.V9I2.5662
  5. Azizah, R. N., Emelda, A., & Asmaliani, I. (2023). Potensi Tanaman Krokot (Portulaca oleraceae) sebagai Bahan Obat Antiobesitas. Solok: Yayasan Pendidikan Cendekia Muslim.
  6. Azizah, R. N., Putra, B., & Tobis, R. (2018). Uji Aktivitas Hipolipidemik Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Pada Tikus Obesitas Dengan Parameter Trigliserida. As-Syifaa Jurnal Farmasi, 10(1), 66–73. https://doi.org/10.56711/JIFA.V10I1.332
  7. Chen, M., Long, Z., Wang, Y., Liu, J., Pian, H., Wang, L., & Chen, Z. (2012). Protective effects of saponin on a hypertension target organ in spontaneously hypertensive rats. Experimental and Therapeutic Medicine, 5(2), 429. https://doi.org/10.3892/ETM.2012.856
  8. Devagaran, T., & Diantini, A. (2012). Senyawa Imunomodulator Dari Tanaman. Bandung: Student eJournal.
  9. Dinas Kesehatan Provinsi Sulawesi Selatan. (2020). Profil Kesehatan Provinsi Sulawesi Selatan. Sulawesi Selatan: Dinas Kesehatan Provinsi Sulawesi Selatan.
  10. Elisa, N., Anggoro, A. B., & Indriyanti, E. (2021). Aktivitas Antihipertensi Ekstrak dan Fraksi-Fraksi Daun Avokad (Persea americana Mill) pada Tikus Jantan dengan Parameter Sistolik dan Diastolik. Jurnal Ilmiah Sains, 21(2), 145–154. https://doi.org/10.35799/JIS.V21I2.35625
  11. Gabb, G. (2020). What is hypertension? Australian Prescriber, 43(4), 108. https://doi.org/10.18773/AUSTPRESCR.2020.025
  12. Guerrero, L., Castillo, J., Quiñones, M., Garcia-Vallvé, S., Arola, L., Pujadas, G., & Muguerza, B. (2012). Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies. PLoS ONE, 7(11), e49493. https://doi.org/10.1371/JOURNAL.PONE.0049493
  13. Hariawan, H., & Tatisina, C. M. (2020). Pelaksanaan Pemberdayaan Keluarga Dan Senam Hipertensi Sebagai Upaya Manajemen Diri Penderita Hipertensi. Jurnal Pengabdian Masyarakat Sasambo, 1(2), 75–79. https://doi.org/10.32807/JPMS.V1I2.478
  14. Harrison, D. G., Coffman, T. M., & Wilcox, C. S. (2021). Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circulation Research, 128(7), 847–863. https://doi.org/10.1161/CIRCRESAHA.121.318082
  15. Husein, S. G., Sundalian, M., & Husna, N. (2021). Review: Analisis Komponen Senyawa Kimia Krokot (Portulaca oleraceae L. dan Portulaca grandiflora Hook.): Review: Component Analysis of Purslanes Chemicals Compound (Portulaca oleraceae L. andPortulaca grandiflora Hook.). Jurnal Sains Dan Kesehatan, 3(2), 317–327. https://doi.org/10.25026/JSK.V3I2.278
  16. Hypertension. (n.d.). Retrieved May 22, 2024, from https://www.who.int/news-room/fact-sheets/detail/hypertension
  17. Irfayanti, N. A., Zam, A. N. Z., & Ayu, M. (2023). Efektivitas Antihipertensi Ekstrak Etanol Rimpang Dringo (Acorus calamus L.) pada Tikus (Rattus norvegicus) yang Diinduksi Prednison dan NaCl. Jurnal Novem Medika Farmasi, 1(3), 22–30. https://doi.org/10.59638/JUNOMEFAR.V1I3.538
  18. Kamyab, R., Namdar, H., Torbati, M., Ghojazadeh, M., Araj-Khodaei, M., & Fazljou, S. M. B. (2021). Medicinal Plants in the Treatment of Hypertension: A Review. Advanced Pharmaceutical Bulletin, 11(4), 601. https://doi.org/10.34172/APB.2021.090
  19. Katzung, B. G., Masters, S. B., & Trevor, A. J. (2014). Farmakologi Dasar dan Klinik Terjemahan. Jakarta: Penerbit Buku Kedokteran EGC.
  20. Kemenkes RI. (2010). Suplemen I Farmakope Herbal Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia.
  21. Kementrian Kesehatan RI. (2018). Hasil Utama Riskesdas. Jakarta: Badan Penelitian dan Pengembangan Kesehatan.
  22. Lestari, K. S., Susilawati, E., Istiqomah, A. N., Amalia, S. N., & Aligita, W. (2023). Aktivitas Antihipertensi Ekstrak Etanol Daun Matoa (Pometia pinnata J.R.Forst. & G.Forst.) Pada Model Hewan Hipertensi Yang Diinduksi Prednison Dan NaCl. Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi Dan Kesehatan, 8(1), 49–58. https://doi.org/10.36387/jiis.v8i1.1103
  23. Lilly, L. S. (2016). Pathophysiology of heart disease: a collaborative project of medical students and faculty / editor Leonard S. Lilly. 6th ed. Philadelphia, USA.: A Wolters Kluwer business,.
  24. Maaliki, D., Shaito, A. A., Pintus, G., El-Yazbi, A., & Eid, A. H. (2019). Flavonoids in hypertension: a brief review of the underlying mechanisms. Current Opinion in Pharmacology, 45, 57–65. https://doi.org/10.1016/J.COPH.2019.04.014
  25. Machsus, A. L., Anggraeni, A., Indriyani, D., Anggraini, D. S., Putra, D. P., Rahmawati, D., … Nurhaliza Z, N. (2020). Pengobatan Hipertensi Dengan Memperbaiki Pola Hidup Dalam Upaya Pencegahan Meningkatnya Tekanan Darah. Journal of Science, Technology and Entrepreneur, 2(2), 51–56. Retrieved from https://ejournal.umbandung.ac.id/index.php/jste/article/view/26
  26. Marwah, Putra, B., & Azizah, R. N. (2023). Pengaruh Pemberian Teh Krokot (Portulaca aoleracea L) Sebagai Antiobesitas Pada Tikus (Rattus norvegicus) Jantan (Skripsi). Fakultas Farmasi, Univeristas Muslim Indonesia, Makassar.
  27. Meharie, B. G., & Tunta, T. A. (2020). Evaluation of Diuretic Activity and Phytochemical Contents of Aqueous Extract of the Shoot Apex of Podocarpus falcactus. Journal of Experimental Pharmacology, 12, 629. https://doi.org/10.2147/JEP.S287277
  28. Meher, M., Pradhan, S., & Pradhan, S. R. (2023). Risk Factors Associated With Hypertension in Young Adults: A Systematic Review. Cureus, 15(4). https://doi.org/10.7759/CUREUS.37467
  29. Monteiro, N. O., Monteiro, T. de M., Nogueira, T. S. R., Cesar, J. R., Nascimento, L. P. S., Campelo, K. A., … Vieira, I. J. C. (2022). Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats. Molecules, 27(20), 6895. https://doi.org/10.3390/MOLECULES27206895/S1
  30. Musfirah, & Masriadi. (2019). Analisis Faktor Risiko dengan Kejadian Hipertensi di Wilayah Kerja Puskesmas Takalala Kecamatan Marioriwawo Kabupaten Soppeng. Jurnal Kesehatan Global, 2(2), 93–102. https://doi.org/10.33085/JKG.V2I2.4316
  31. P2PTM Kemenkes RI. (n.d.). Apa itu Hipertensi (Tekanan Darah Tinggi) ? - Penyakit Tidak Menular Indonesia. Retrieved May 22, 2024, from https://p2ptm.kemkes.go.id/infographic/apa-itu-hipertensi-tekanan-darah-tinggi
  32. Paramita, S., Isnuwardana, R., Nuryanto, M. K., Djalung, R., Rachmawatiningtyas, D. G., & Jayastri, P. (2017). Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas. Jurnal Sains Dan Kesehatan, 1(7), 367–376. https://doi.org/10.25026/JSK.V1I7.56
  33. Permatasari, D. A. I., Wardani, T. S., Rahmasari, I., & Dewi, K. P. M. (2021). Antioxidant Activity Of Purslane Plant (Portulaca oleracea L.) Extract As An Antiaging Serum In Spray Gel Using DPPH Method. Jurnal Farmasi Sains Dan Praktis, 7(3), 269–281. https://doi.org/10.31603/PHARMACY.V7I3.6084
  34. Permatasari, R., Suriani, E., & Kurniawan, K. (2022). Hubungan Kadar Kolesterol Total Dengan Tekanan Darah Pada Pasien Hipertensi Pada Usia ≥ 40 Tahun. Jurnal Labora Medika, 6(1), 16–21. https://doi.org/10.26714/JLABMED.6.1.2022.16-21
  35. Purwidyaningrum, I., Sukandar, E. Y., & Fidrianny, I. (2017). Antihypertensive Activity Of Extract And Fractions Of Matoa (Pometia pinnata J. R & G Forts) Leaves. Asian Journal of Pharmaceutical and Clinical Research, 10(3), 323. https://doi.org/10.22159/ajpcr.2017.v10i3.16221
  36. Rahma, A. (2018). Skrinning Aktivitas Antihipertensi dari ekstrak etanol 70% rimpang: Jahe merah (ZIngiber officinalle Roscoe), Bangle (ZIngiber Purpureum Roscoe), Temu kunci (Boesenbergia rotunda (L) Mansf) dan Temu Putih (kaempferia rotunda L), pada tikus yang diinduksi adrenalin (Skripsi). Fakultas Ilmu kesehatan: UIN Syarif Hidayatullah, Jakarta.
  37. Rahmadhani, M. (2021). Faktor-Faktor Yang Mempengaruhi Terjadinya Hipertensi Pada Masyarakat Di Kampung Bedagai Kota Pinang. Jurnal Kedokteran STM (Sains Dan Teknologi Medik), 4(1), 52–62. https://doi.org/10.30743/STM.V4I1.132
  38. Santi, I., Azizah, R. N., & Mu’ammar, M. (2018). Penentuan Dosis Minimum Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Terhadap Penurunan Kadar Trigliserida Pada Tikus Obesitas. As-Syifaa Jurnal Farmasi, 10(2), 205–212. https://doi.org/10.56711/JIFA.V10I2.419
  39. Setiawati, A., & Bustami, Z. S. (1995). Antihipertensi, Farmakologi dan Terapi, Edisi IV. Jakarta: Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia.
  40. Singh, S., Shankar, R., & Singh, G. P. (2017). Prevalence and Associated Risk Factors of Hypertension: A Cross-Sectional Study in Urban Varanasi. International Journal of Hypertension, 2017. https://doi.org/10.1155/2017/5491838
  41. Sitti Fauziah Noer, A., Alfiah Irfayanti, N., & Muna Rahmat, I. (2023). Aktivitas Antihipertensi Ekstrak Etanol Daun Alpukat (Persea americana Mill.) Pada Tikus Putih (Rattus norvegicus). Media Farmasi, 19(2), 87–95. https://doi.org/10.32382/MF.V19I2.121
  42. Susilowati, A., Urfiyya, Q. ‘Aina, Wijaya, A., Sundu, R., & Supriningrum, R. (2024). Perbandingan Efek Antihipertensi Ekstrak Etanol White Tea, Yellow Tea, Black Dragon Tea dan Green Tea. Media Farmasi, 20(1), 101–109. https://doi.org/10.32382/MF.V20I1.236
  43. Tyashapsari, M. W. E., & Zulkarnain, A. K. (2017). Penggunaan obat pada pasien hipertensi di instalasi rawat inap rumah sakit umum pusat dr. Kariadi semarang. Majalah Farmaseutik, 8(2), 145–151. https://doi.org/10.22146/FARMASEUTIK.V8I2.24068
  44. Zhou, Y.-X., Xin, H.-L., Rahman, K., Wang, S.-J., Peng, C., & Zhang, H. (2015). Portulaca oleracea L.: A Review of Phytochemistry and Pharmacological Effects. BioMed Research International, 2015, 1–11. https://doi.org/10.1155/2015/925631