Main Article Content

Abstract

The most effective therapeutic management in schizophrenia patients is antipsychotic therapy. Antipsychotic groups are divided into two categories: first-generation and second-generation antipsychotics. Antipsychotic administration can cause side effects such as extrapyramidal symptoms. This study aims to determine the effect of giving a combination of antipsychotics on the side effects of extrapyramidal syndrome in hospitalized schizophrenia patients at Sambang Lihum Mental Hospital. This study employed a non-experimental observational analytic approach with prospective data collection. The study population consisted of all schizophrenia patients who were hospitalized between January and February 2022. The sample size was 122 patient medical records, obtained through purposive sampling. The instruments used to measure the variables included respondent characteristics (age, gender, latest education, occupation, marital status, history of diagnosis, and history of extrapyramidal syndrome) and the incidence of extrapyramidal syndrome side effects, which were documented in essays written by the researcher. The data analysis employed univariate (frequency, percentage) and bivariate (chi-square test) techniques. The results of the study yielded a description of the administration of antipsychotic combinations in hospitalized schizophrenia patients at Sambang Lihum Mental Hospital. The most prevalent combination was the Atypical-Typical combination, which was administered to 58.2% of patients. There were no instances of extrapyramidal syndrome side effects from the administration of a combination of antipsychotics, with 86.9% of patients experiencing no adverse effects. The administration of a combination of antipsychotics does not appear to affect the incidence of extrapyramidal syndrome in schizophrenic patients.

Keywords

antipsikotik syndrom extrapiramidal skizofreniaa

Article Details

Author Biographies

Helmina wati, Universitas Borneo Lestari

Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Borneo Lestari, Banjarbaru, Indonesia

Rahmi Hidayati, Universitas Borneo Lestari

Program Studi PGSD, Fakultas Ilmu Sosial dan Humaniora, Universitas Borneo Lestari,Kalimantan Selatan, Indonesia

Muhammad Rizky Wardani, Rumah Sakit Jiwa Sambang Lihum

Rumah Sakit Jiwa Sambang Lihum Banjarbaru
How to Cite
wati, H., Hidayati, R., & Wardani, M. R. (2024). Pengaruh Kombinasi Antipsikotik Tehadap Efek Samping Sindrom Ekstrapiramidal Pasien Skizofrenia Rawat Inap Rumah Sakit Jiwa Sambang Lihum Banjarbaru. Borneo Journal of Pharmascientech, 8(1), 78-89. https://doi.org/10.51817/bjp.v8i1.529

References

  1. Ainni, A.N. 2022. Adverse Drug Reactions Penggunaan Obat Antipsikotik Pasien ResiduaI Skizofrenia di SaIah Satu Rumah Sakit Purworejo Daerah Jawa Tengah. Tesis, Program Studi Magister Farmasi SekoIah Pascasarjana Universitas Muhammadiyah Surakarta, Surakarta.
  2. Dania, H., I.N. Faridah, K.F. Rahmah, R.AbduIah, M.I. BarIiana, & D.A. Perwitasari. 2019. Hubungan Pemberian Terapi Antipsikotik Terhadap Kejadian Efek Samping Sindrom EkstrapiramidaI Pada Pasien Rawat JaIan di SaIah Satu Rumah Sakit di BantuI Yogyakarta. JurnaI Farmasi KIinik Indonesia. 8: 19-30.
  3. DiPiro, J.T., R.I. TaIbert, G.C. Yee, G.R. Matzke, B.G. WeIIs, & I. M. Posey. 2017. Pharmacotherapy A PathophysioIogic Approach Tenth Edition. Mc Graw HiII, New York.
  4. Handayani, D.S., N. Cahaya, & V.M Srikartika. 2017. Pengaruh Pemberian Kombinasi Antipsikotik Terhadap Efek Samping Sindrom EkstrapiramidaI Pada Pasien Skizofrenia di Rumah Sakit Jiwa Sambang Iihum. Farmaka. 15: 86-95.
  5. Hasni, D., M. Ridho, & M. Anissa. 2019. Gambaran Sindrom EkstrapiramidaI Pada Pasien Skizofrenia yang Mendapat Terapi Antipsikotik. Padang. JurnaI Kedokteram Yarsi. 27: 090-094.
  6. LaIIy, J. & J.H. Maccabe. 2015. Antipsychotic Medication In Schizophrenia : A Review. Br Med BuII. 114: 169-179.
  7. MayIani, R.Y., J. Fadraersada, & A.M. Ramadhan. 2018. Studi Pemberian Antipsikotik Terhadap Beberapa Jenis Skizofrenia Di RSJD Atma Husada Mahakam Samarinda. Proceeding of the 8th MuIawarman PharmaceuticaIs Conferences. 1: 267-275.
  8. Rahaya, A, & Cahaya, N. 2016. Studi Retrospektif Penggunaan Trihexyfenidil Pada Pasien Skizofrenia Rawat Inap Yang Mendapat Terapi Antipsikotik Di Rumah Sakit Jiwa Sambang Lihum. Banjarmasin. Galenika Jurnal of Pharmacy Vol.2 (2) : 124-131.
  9. Ren, Y., H. Wang., & I. Xiao. 2013. Improving MyeIin OIigodendrocyte ReIated Dysfunction: A New Mechanism Of Antipsychotics In The Treatment Of Schizophrenia. InternationaI JournaI of NeuropsychopharmacoIogy. 16: 691-700.
  10. Stroup, T.S. & N. Gray. 2018. Management of Common Adverse Effects of Antipsychotic Medications. WorId Psychiatry. 17: 341–356.
  11. Subramaniam, S., N.P.S. Sasmita, & C.B.J. Iesmana. 2018. PrevaIensi Efek Samping Farmakoterapi Terhadap Penderita Skizofrenia di Rumah Sakit Jiwa BangIi, Propinsi BaIi. E-jurnaI Medika. 7: 22-27.
  12. Sugiarto & M. YuIistiani. 2020. Karakteristik Pasien EktrapiramidaI Sindrom. Adi Husada Nursing JournaI. 6: 106-111.
  13. Sugiarto & M. YuIistiani. 2020. Karakteristik Pasien EktrapiramidaI Sindrom. Adi Husada Nursing JournaI. 6: 106-111.
  14. Susanti, S.D.T. 2020. EvaIuasi DRPs Penggunaan Antipsikotik Pada Pasien Skizofrenia di RSJ Dr. Radjiman Wediodiningrat Iawang Tahun 2019. Skripsi. Program Studi Farmasi FakuItas Kedokteran Dan IImu Kesehatan, Universitas IsIam Negeri MauIana MaIik Ibrahim MaIang, MaIang.
  15. YuIianty, M.D., N. Cahaya, & V.M Srikartika. 2017. Studi Penggunaan Antipsikotik dan Efek Samping pada Pasien Skizofrenia di Rumah Sakit Jiwa Sambang Iihum KaIimantan SeIatan. JurnaI Sains Farmasi & KIinis. 3: 153-164.